Phylogenetic reconstruction of vertebrate Hox cluster duplications

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Phylogenetic reconstruction of vertebrate Hox cluster duplications.

In vertebrates and the cephalochordate, amphioxus, the closest vertebrate relative, Hox genes are linked in a single cluster. Accompanying the emergence of higher vertebrates, the Hox gene cluster duplicated in either a single step or multiple steps, resulting in the four-cluster state present in teleosts and tetrapods. Mammalian Hox clusters (designated A, B, C, and D) extend over 100 kb and a...

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Hox genes play a key role in animal body plan development. These genes tend to occur in tightly linked clusters in the genome. Vertebrates and invertebrates differ in their Hox cluster number, with vertebrates having multiple clusters and invertebrates usually having only one. Recent evidence shows that vertebrate Hox clusters are structurally more constrained than invertebrate Hox clusters; th...

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ژورنال

عنوان ژورنال: Molecular Biology and Evolution

سال: 1997

ISSN: 0737-4038,1537-1719

DOI: 10.1093/oxfordjournals.molbev.a025825